Article
Small cell lung cancer transformation and T790M mutation: complimentary roles in acquired resistance to kinase inhibitors in lung cancer.
Scientific reports - 24 Sept 2015
Suda Kenichi, Murakami Isao, Sakai Kazuko, Mizuuchi Hiroshi, Shimizu Shigeki, Sato Katsuaki, Tomizawa Kenji, Tomida Shuta, Yatabe Yasushi, Nishio Kazuto, Mitsudomi Tetsuya
Abstract excerpt
Lung cancers often harbour a mutation in the epidermal growth factor receptor (EGFR) gene. Because proliferation and survival of lung cancers with EGFR mutation solely depend on aberrant signalling from the mutated EGFR, these tumours often show dramatic responses to EGFR tyrosine kinase inhibitors (TKIs). However, acquiring resistance to these drugs is almost inevitable, thus a better understanding of the...
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