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Article

Small-cell lung cancer transformation from EGFR-mutant adenocarcinoma after EGFR-TKIs resistance: A case report.

Medicine - 13 Aug 2021

Jiang Yiqian, Shou Leyi, Guo Qingmin, Bao Yanhong, Xu Xiaoping, An Suhong, Lu Jianfeng

Abstract excerpt

RATIONALE: With the recent advancements in molecular biology research, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have emerged as excellent therapies for patients with EGFR-mutant cancers. However, these patients inevitably develop cross-acquired resistance to EGFR-TKIs. Transformation to small-cell lung cancer (SCLC) is considered a rare resistance mechanism against EGFR-TKI therapy....

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Share to Adenocarcinoma of Lung
Share to Biopsy
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ErbB Receptors

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Share to Small Cell Lung Carcinoma

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Identifiers

PMID: 34397927
DOI: 10.1097/MD.0000000000026911
PMCID: PMC8360407

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