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Article

Small-cell carcinoma in the setting of pulmonary adenocarcinoma: new insights in the era of molecular pathology.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2013

Norkowski Emma, Ghigna Maria-Rosa, Lacroix Ludovic, Le Chevalier Thierry, Fadel Élie, Dartevelle Philippe, Dorfmuller Peter, Thomas de Montpréville Vincent

Abstract excerpt

INTRODUCTION: Transformation into small-cell lung carcinoma (SCLC) has been reported as an evolution of lung adenocarcinoma acquiring resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). However, spontaneous association of SCLC and adenocarcinoma also exists. We sought to compare patients' clinical features and mutation status of EGFR in each tumor component in these conditions....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24457237
DOI: 10.1097/JTO.0b013e3182a407fa

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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