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An EGFR-mutant lung adenocarcinoma that transformed into small-cell lung cancer. A case report.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia - 1 Dec 2022

Chowaniecova Gabriela, Berzinec Peter, Kosturiakova Gabriela, Plank Lukas, Farkasova Anna, Sekeresova Monika, Juskanic Dominik, Ondrus Dalibor

Abstract excerpt

BACKGROUND: Transformation of EGFR (epidermal growth factor receptor) - mutant non-small cell lung cancer (NSCLC) into small-cell lung cancer (SCLC) is one mechanism of resistance to tyrosine kinase inhibitor (TKI) treatment, seen in approximately 3-10% cases. Such transformed SCLC often retains the original EGFR mutation (EGFRM), which is not otherwise observed in SCLC. CASE REPORT: We present a 67 y/o woman...

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Identifiers

PMID: 36036563
DOI: 10.5507/bp.2022.037

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