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Article

Large Cell Neuroendocrine Carcinoma Transformation and EGFR-T790M Mutation as Coexisting Mechanisms of Acquired Resistance to EGFR-TKIs in Lung Cancer.

Mayo Clinic proceedings - 1 Aug 2017

Baglivo Sara, Ludovini Vienna, Sidoni Angelo, Metro Giulio, Ricciuti Biagio, Siggillino Annamaria, Rebonato Alberto, Messina Salvatore, Crinò Lucio, Chiari Rita

Abstract excerpt

Acquired resistance to tyrosine kinase inhibitors (TKIs) represents the Achilles' heel of targeted treatment in lung cancer. Epidermal growth factor receptor (EGFR)-TKIs are considered the standard first-line treatment for patients with EGFR mutant non-small cell lung cancer; however, after a median of 9 to 12 months, virtually all patients develop acquired resistance, which is mediated by the development of an...

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Identifiers

PMID: 28778263
DOI: 10.1016/j.mayocp.2017.03.022

Genes

EGFR

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