Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea.

doi:10.1097/FPC.0b013e328300e8c5

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Article

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea.

Pharmacogenetics and genomics - 1 Jul 2008

Becker Matthijs L, Aarnoudse Albert-Jan L H J, Newton-Cheh Christopher, Hofman Albert, Witteman Jacqueline C M, Uitterlinden André G, Visser Loes E, Stricker Bruno H Ch

Abstract excerpt

OBJECTIVE: The single nucleotide polymorphism rs10494366 in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene is associated with QTc prolongation, through an effect on the intracellular Ca levels. As sulfonylurea stimulate insulin secretion by an increased influx of Ca, we hypothesized that this polymorphism is associated with the glucose-lowering effect and mortality risk in sulfonylurea users. METHODS:...

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PMID: 18551039
DOI: 10.1097/FPC.0b013e328300e8c5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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