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Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer

28 Mar 2023

Abstract excerpt

Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of tumor relapse following primary debulking, and the development of chemoresistance. All these events are thought to be initiated and sustained by a subpopulation of neoplastic cells, termed ovarian cancer stem cells (OCSC), that are endowed with self-renewing and...

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PMID: 36977707
DOI: 10.1038/s41419-023-05760-w

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