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Article

Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.

Oncology research - 29 May 2020

Yin Ping, Wang Wei, Gao Jian, Bai Yu, Wang Zhuo, Na Lei, Sun Yu, Zhao Chenghai

Abstract excerpt

Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC) cell stemness via noncanonical Wnt pathways. Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2 knockdown (KD) disturbed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Source

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Identifiers

PMID: 31907106
DOI: 10.3727/096504020X15783052025051
PMCID: PMC7851528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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