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The S2 Glycoprotein Subunit Determines Intestinal Tropism in Infectious Bronchitis Virus

17 Aug 2025

Abstract excerpt

The molecular basis for the distinct intestinal tropism of infectious bronchitis virus (IBV) strains remains poorly understood. This study identifies the S2 subunit of the spike glycoprotein as the critical determinant conferring duodenal tropism to the IBV CSL strain. Comparative pathogenesis in specific-pathogen-free (SPF) chicks revealed that the CSL strain achieved significantly higher viral titers in the...

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PMID: 40871421
DOI: 10.3390/microorganisms13081918

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