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The V577S mutation in the S2 subunit of QX-type IBV attenuates viral adaptation to chicken oviduct epithelial cells and pathogenicity in laying hens.

Molecular biology reports - 17 Aug 2026

Zhang Haili, Huang Yamei, Li Shuyun, Shen Yuxi, Xia Jing, Huang Yong

Abstract excerpt

BACKGROUND: The cell and tissue tropism of infectious bronchitis virus (IBV) varies among strains and genotypes, with the S2 subunit of the spike protein serving as a key determinant. METHODS AND RESULTS: In this study, we compared S2 sequences of IBV strains with distinct adaptation to chicken oviduct epithelial cells (COEC) and identified seven potential sites associated with COEC adaptation. Using the highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42606783
DOI: 10.1007/s11033-026-12600-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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