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Article

Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2021

Jo Wendy K, Schadenhofer Alina, Habierski Andre, Kaiser Franziska K, Saletti Giulietta, Ganzenmueller Tina, Hage Elias, Haid Sibylle, Pietschmann Thomas, Hansen Gesine, Schulz Thomas F, Rimmelzwaan Guus F, Osterhaus Albert D M E, Ludlow Martin

Abstract excerpt

Human respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection in children under 5 y of age. In the absence of a safe and effective vaccine and with limited options for therapeutic interventions, uncontrolled epidemics of RSV occur annually worldwide. Existing RSV reverse genetics systems have been predominantly based on older laboratory-adapted strains such as A2 or Long. These...

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Identifiers

PMID: 33811145
DOI: 10.1073/pnas.2026558118
PMCID: PMC8040649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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