Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus.

Virus research - 2 May 2018

Shan Dan, Fang Shouguo, Han Zongxi, Ai Hui, Zhao Wenjun, Chen Yuqiu, Jiang Lei, Liu Shengwang

Abstract excerpt

To study the roles of hypervariable regions (HVRs) in receptor-binding subunit S1 of the spike protein, we manipulated the genome of the IBV Beaudette strain using a reverse genetics system to construct seven recombinant strains by separately or simultaneously replacing the three HVRs of the Beaudette strain with the corresponding fragments from a QX-like nephropathogenic isolate ck/CH/LDL/091022 from China. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infectious bronchitis virus

Share to Reverse Genetics

Share to Serogroup

Share to Spike Glycoprotein, Coronavirus

Share to Vero Cells

Share to Viral Tropism

Source

Open in PubMed Open full text

Identifiers

PMID: 29684409
DOI: 10.1016/j.virusres.2018.04.013
PMCID: PMC7114591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus.PMID 29684409Read ↗

A new genotype of nephropathogenic infectious bronchitis virus circulating in vaccinated and non-vaccinated flocks in China.Semantic proximity Read ↗

Antigenic and Pathogenic Characteristics of QX-Type Avian Infectious Bronchitis Virus Strains Isolated in Southwestern China.Semantic proximity Read ↗

Sequence analysis of nephropathogenic infectious bronchitis virus strains of the Massachusetts genotype in BeijingSemantic proximity Read ↗

Two mutations on S2 subunit were critical for Vero cell tropism expansion of infectious bronchitis virus HV80.Semantic proximity Read ↗

The N545S and K717N substitution at the N-glycosylation sites of the S2 subunit of avian infectious bronchitis virus can significantly enhance viral pathogenicitySemantic proximity Read ↗

Analysis of antigenicity and pathogenicity reveals major differences among QX-like infectious bronchitis viruses and other serotypes.Semantic proximity Read ↗

Genetic Characterization of the Belgian Nephropathogenic Infectious Bronchitis Virus (NIBV) Reference Strain B1648.Semantic proximity Read ↗

Recombinant Infectious Bronchitis Coronavirus Beaudette with the Spike Protein Gene of the Pathogenic M41 Strain Remains Attenuated but Induces Protective ImmunitySemantic proximity Read ↗

Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited ReplicationIn VivoSemantic proximity Read ↗

Recombinant infectious bronchitis coronavirus H120 with the spike protein S1 gene of the nephropathogenic IBYZ strain remains attenuated but induces protective immunitySemantic proximity Read ↗

Limited Cross-Protection against Infectious Bronchitis Provided by Recombinant Infectious Bronchitis Viruses Expressing Heterologous Spike GlycoproteinsSemantic proximity Read ↗

A Recombinant Avian Infectious Bronchitis Virus Expressing a Heterologous Spike Gene Belonging to the 4/91 SerotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.