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Article

Variability of polygenic prediction for body mass index in Africa.

Genome medicine - 30 May 2024

Chikowore Tinashe, Läll Kristi, Micklesfield Lisa K, Lombard Zane, Goedecke Julia H, Fatumo Segun, Norris Shane A, Magi Reedik, Ramsay Michele, Franks Paul W, Pare Guillaume, Morris Andrew P

Abstract excerpt

BACKGROUND: Polygenic prediction studies in continental Africans are scarce. Africa's genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the continent. Studies to understand the factors that affect PRS variability within Africa are required. METHODS: Using the first multi-ancestry genome-wide association study...

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Identifiers

PMID: 38816834
DOI: 10.1186/s13073-024-01348-x
PMCID: PMC11140909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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