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Article

EHMT2-mediated transcriptional reprogramming drives neuroendocrine transformation in non–small cell lung cancer

30 May 2024

Abstract excerpt

The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) is a recognized resistance mechanism and a hindrance to therapies using epidermal growth factor receptor tyrosine kinase inhibitors (TKIs). The paucity of pretranslational/posttranslational clinical samples limits the deeper understanding of resistance mechanisms and the exploration of effective therapeutic strategies. Here, we developed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38814866
DOI: 10.1073/pnas.2317790121

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