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Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions

29 May 2024

Abstract excerpt

The molecular mechanisms governing the response of hematopoietic stem cells (HSCs) to stress insults remain poorly defined. Here, we investigated effects of conditional knock-out or overexpression of Hmga2 (High mobility group AT-hook 2), a transcriptional activator of stem cell genes in fetal HSCs. While Hmga2 overexpression did not affect adult hematopoiesis under homeostasis, it accelerated HSC expansion in...

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PMID: 38811851
DOI: 10.1038/s44318-024-00122-4

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