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High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote Tumorigenesis

3 May 2011

Abstract excerpt

The high-mobility group A2 gene (HMGA2) is one of the most frequently amplified genes in human cancers. However, functions of HMGA2 in tumorigenesis are not fully understood due to limited knowledge of its targets in tumor cells. Our study reveals a novel link between HMGA2 and the regulation of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, which offers critical insight into...

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PMID: 21536653
DOI: 10.1128/mcb.05447-11

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