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Mutations in the NDV fusion protein HR4 region decreased fusogenic activity due to failed protein expression.

Microbial pathogenesis - 1 Jul 2024

Liu Yaqing, Pan Huazheng, Wang Hongwei, Yuan Yuan, Cao Fangfang, Song Wei, Wang Zhiyu

Abstract excerpt

Newcastle disease virus (NDV) is the pathogen of a zoonosis that is primarily transmitted by poultry and has severe infectivity and a high fatality rate. Many studies have focused on the role of the NDV fusion (F) protein in the cell-cell membrane fusion process. However, little attention has been given to the heptad repeat region, HR4, which is located in the NDV F2 subunit. Here, site-directed mutants were...

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Identifiers

PMID: 38810765
DOI: 10.1016/j.micpath.2024.106713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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