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Article

Mutations in the NDV fusion protein HR4 region decreased fusogenic activity due to failed protein expression.

Microbial pathogenesis - 1 Jul 2024

Liu Yaqing, Pan Huazheng, Wang Hongwei, Yuan Yuan, Cao Fangfang, Song Wei, Wang Zhiyu

Abstract excerpt

Newcastle disease virus (NDV) is the pathogen of a zoonosis that is primarily transmitted by poultry and has severe infectivity and a high fatality rate. Many studies have focused on the role of the NDV fusion (F) protein in the cell-cell membrane fusion process. However, little attention has bee...

Topics

Newcastle disease virus
Viral Fusion Proteins
Animals
Virus Internalization
Mutagenesis, Site-Directed
Amino Acid Substitution
Cell Line
Mutation
Proteolysis
Membrane Fusion

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Identifiers

PMID: 38810765
DOI: 10.1016/j.micpath.2024.106713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38810765-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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