Article
Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo.
Viruses - 25 Oct 2022
Lu Xiaolong, Zhan Tiansong, Liu Kaituo, Chen Yu, Hu Zenglei, Hu Jiao, Gu Min, Hu Shunlin, Wang Xiaoquan, Liu Xiaowen, Liu Xiufan
Abstract excerpt
As a multifunctional protein, the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is involved in various biological functions. A velogenic genotype III NDV JS/7/05/Ch evolving from the mesogenic vaccine strain Mukteswar showed major amino acid (aa) mutations in the HN pr...
Topics
- Animals
- Newcastle disease virus
- HN Protein
- Neuraminidase
- Hemagglutinins
- Chickens
- Genotype
- Mutation