Article
Biological Significance of Dual Mutations A494D and E495K of the Genotype III Newcastle Disease Virus Hemagglutinin-Neuraminidase In Vitro and In Vivo.
Viruses - 25 Oct 2022
Lu Xiaolong, Zhan Tiansong, Liu Kaituo, Chen Yu, Hu Zenglei, Hu Jiao, Gu Min, Hu Shunlin, Wang Xiaoquan, Liu Xiaowen, Liu Xiufan
Abstract excerpt
As a multifunctional protein, the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is involved in various biological functions. A velogenic genotype III NDV JS/7/05/Ch evolving from the mesogenic vaccine strain Mukteswar showed major amino acid (aa) mutations in the HN protein. However, the precise biological significance of the mutant HN protein remains unclear. This study sought to...
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