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Article

Two mutations in the HR2 region of Newcastle disease virus fusion protein with a cleavage motif "RRQRRL" are critical for fusogenic activity.

Virology journal - 25 Sept 2017

Wang Yanhong, Bi Youkun, Yu Wanqi, Wei Ning, Wang Wenbin, Wei Qiaolin, Wang Xinglong, Zhang Shuxia, Yang Zengqi, Xiao Sa

Abstract excerpt

BACKGROUND: Newcastle disease virus (NDV) causes severe diseases in avian species. Its fusion protein cleavage site (Fcs) is a major contributor to virulence and membrane fusion. Previous studies showed that a change from phenylalanine (F) to lysine (L) at position 117 of the virulent strain fusion protein, which has the polybasic amino acid Fcs motif "112RRQKR↓F117", blocked syncytium formation. However, we...

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Identifiers

PMID: 28946881
DOI: 10.1186/s12985-017-0851-0
PMCID: PMC5613334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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