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Article

Mutations in the fusion peptide and adjacent heptad repeat inhibit folding or activity of the Newcastle disease virus fusion protein.

Journal of virology - 1 Sept 2001

Sergel T A, McGinnes L W, Morrison T G

Abstract excerpt

Paramyxovirus fusion proteins have two heptad repeat domains, HR1 and HR2, which have been implicated in the fusion activity of the protein. Peptides with sequences from these two domains form a six-stranded coiled coil, with the HR1 sequences forming a central trimer (K. A. Baker, R. E. Dutch, R. A. Lamb, and T. S. Jardetzky, Mol. Cell 3:309-319, 1999; X. Zhao, M. Singh, V. N. Malashkevich, and P. S. Kim, Proc....

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Identifiers

PMID: 11483738
DOI: 10.1128/jvi.75.17.7934-7943.2001
PMCID: PMC115037

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