Article
Mutagenesis of the di-leucine motif in the cytoplasmic tail of newcastle disease virus fusion protein modulates the viral fusion ability and pathogenesis.
Virology journal - 9 Feb 2023
Teng Qingyuan, Tang Lihua, Huang Yahui, Yang Ruihua, He Yizhuo, Zhang Guozhong, Zhao Ye
Abstract excerpt
BACKGROUND: Newcastle disease virus (NDV) is a highly infectious viral disease, which can affect chickens and many other kinds of birds. The main virulence factor of NDV, the fusion (F) protein, is located on the viral envelope and plays a major role in the virus' ability to penetrate cells and cause host cell fusion during infection. Multiple highly conserved tyrosine and di-leucine (LL) motifs in the...
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