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Article

Spring-loaded heptad repeat residues regulate the expression and activation of paramyxovirus fusion protein.

Journal of virology - 1 Apr 2007

Luque Laura E, Russell Charles J

Abstract excerpt

During viral entry, the paramyxovirus fusion (F) protein fuses the viral envelope to a cellular membrane. Similar to other class I viral fusion glycoproteins, the F protein has two heptad repeat regions (HRA and HRB) that are important in membrane fusion and can be targeted by antiviral inhibitors. Upon activation of the F protein, HRA refolds from a spring-loaded, crumpled structure into a coiled coil that...

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Identifiers

PMID: 17251293
DOI: 10.1128/JVI.02464-06
PMCID: PMC1866055

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Source receipt: pubmed, retrieved 7 Sept 2026.

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