Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.

doi:10.1002/alz.13848

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Article

Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2024

Panyard Daniel J, Reus Lianne M, Ali Muhammad, Liu Jihua, Deming Yuetiva K, Lu Qiongshi, Kollmorgen Gwendlyn, Carboni Margherita, Wild Norbert, Visser Pieter J, Bertram Lars, Zetterberg Henrik, Blennow Kaj, Gobom Johan, Western Dan, Sung Yun Ju, Carlsson Cynthia M, Johnson Sterling C, Asthana Sanjay, Cruchaga Carlos, Tijms Betty M, Engelman Corinne D, Snyder Michael P

Abstract excerpt

INTRODUCTION: Recent genome-wide association studies (GWAS) have reported a genetic association with Alzheimer's disease (AD) at the TNIP1/GPX3 locus, but the mechanism is unclear. METHODS: We used cerebrospinal fluid (CSF) proteomics data to test (n = 137) and replicate (n = 446) the association of glutathione peroxidase 3 (GPX3) with CSF biomarkers (including amyloid and tau) and the GWAS-implicated variants...

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Identifiers

PMID: 38809917
DOI: 10.1002/alz.13848
PMCID: PMC11247664

Genes

GPX3
TNIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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