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Article

Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025

Ercan Huriye, Reumiller Christina Maria, Mühlberger Jacqueline, Hsu Felicia, Schmidt Georg Johannes, Umlauf Ellen, Miller Ingrid, Rappold Eduard, Attems Johannes, Oehler Rudolf, Zellner Maria

Abstract excerpt

INTRODUCTION: Blood biomarkers reflecting Alzheimer's disease (AD) pathophysiology can improve diagnosis and treatment. METHODS: We applied top-down proteomics to compare frontal lobe from 17 AD cases and 11 controls to blood platelets from a second independent study group of 124 AD patients, 61 with mild cognitive impairment (MCI), and 168 controls. Findings were immunologically validated. RESULTS: Sixty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40189792
DOI: 10.1002/alz.70117
PMCID: PMC11972982

Genes

CCS
SOD1
GPX1
GSTO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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