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Post-GWAS multiomic functional investigation of the<i>TNIP1</i>locus in Alzheimer’s disease implicates mediation through<i>GPX3</i>

2022-11-05

Abstract excerpt

The recently reported TNIP1 / GPX3 locus from AD GWAS studies was investigated. Using proteomics and other functional omics data, we identified evidence for a functional mechanism linking variants in this locus to decreased CSF GPX3 levels as AD progresses, suggesting a new potential target for intervention.

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Literature Corpus work
429873d3-e8df-55da-adb9-c91d9ab91a3d
DOI
10.1101/2022.11.04.22277162
Open publication

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Post-GWAS multiomic functional investigation of the<i>TNIP1</i>locus in Alzheimer’s disease implicates mediation through<i>GPX3</i>DOI 10.1101/2022.11.04.22277162
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