Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial analysis of recurrent glioblastoma reveals perivascular niche organization.

JCI insight - 23 May 2024

Onubogu Ugoma, Gatenbee Chandler D, Prabhakaran Sandhya, Wolfe Kelsey L, Oakes Benjamin, Salatino Roberto, Vaubel Rachael, Szentirmai Oszkar, Anderson Alexander Ra, Janiszewska Michalina

Abstract excerpt

Tumor evolution is driven by genetic variation; however, it is the tumor microenvironment (TME) that provides the selective pressure contributing to evolution in cancer. Despite high histopathological heterogeneity within glioblastoma (GBM), the most aggressive brain tumor, the interactions between the genetically distinct GBM cells and the surrounding TME are not fully understood. To address this, we analyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Neoplasm Recurrence, Local

Share to Single-Cell Analysis

Share to Spatial Analysis

Share to Telomerase

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 38805346
DOI: 10.1172/jci.insight.179853
PMCID: PMC11383164

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial analysis of recurrent glioblastoma reveals perivascular niche organization.PMID 38805346Read ↗

Local Tumor Microenvironment Niches Correlate With Survival And Immunotherapy Response In Human GlioblastomaSemantic proximity Read ↗

Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactionsSemantic proximity Read ↗

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and their Relationship to Oncogenic DriversSemantic proximity Read ↗

Spatial single-cell profiling of deeply matched extreme long-term surviving glioblastoma patients reveals a distinct immune and stem cell driven ecosystemSemantic proximity Read ↗

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read ↗

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interferenceSemantic proximity Read ↗

Transcriptome analysis reveals tumor microenvironment changes in glioblastomaSemantic proximity Read ↗

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of GlioblastomaSemantic proximity Read ↗

Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmapSemantic proximity Read ↗

Oncogenic drivers shape the tumor microenvironment in human gliomasSemantic proximity Read ↗

Radiogenomics to characterize regional genetic heterogeneity in glioblastomaSemantic proximity Read ↗

Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.