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Article

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

8 Aug 2016

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each tumor comprises multiple genetically distinct clonal populations with different therapeutic sensitivities. This has implications for targeted therapy and genetically informed paradigms. Contrast-enhanced (CE)-MRI and conventional sampling techniques have failed to resolve this heterogeneity, particularly for nonenhancing...

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PMID: 27502248
DOI: 10.1093/neuonc/now135

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