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Article

Multi-omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma.

Clinical and translational medicine - 1 Nov 2023

Huang Haitao, Li Na, Liang Yingkuan, Li Rutao, Tong Xing, Xiao Jinyuan, Tang Hongzhen, Jiang Dong, Xie Kai, Fang Chen, Chen Shaomu, Li Guangbin, Wang Bin, Wang Jiaqian, Luo Haitao, Guo Lingchuan, Ma Haitao, Jiang Wei, Feng Yu

Abstract excerpt

BACKGROUND: Biopsies obtained from primary oesophageal squamous cell carcinoma (ESCC) guide diagnosis and treatment. However, spatial intra-tumoral heterogeneity (ITH) influences biopsy-derived information and patient responsiveness to therapy. Here, we aimed to elucidate the spatial ITH of ESCC and matched lymph node metastasis (LNmet ). METHODS: Primary tumour superficial (PTsup ), deep (PTdeep ) and LNmet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38009315
DOI: 10.1002/ctm2.1493
PMCID: PMC10679972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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