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Article

Integrated Spatial Immune Phenotyping Identifies a Suppressive-infiltrated High-risk Subgroup in Esophageal Squamous Cell Carcinoma.

Anticancer research - 1 Sept 2026

Jiao Wenpeng, Wang Dan, Han Jia, Liu Yao, Yamada Sohsuke

Abstract excerpt

BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) exhibits substantial heterogeneity in its tumor immune microenvironment (TIME). We aimed to establish an integrated spatial immune phenotyping framework incorporating immune infiltration, spatial distribution, and suppressive-effector immune balance. PATIENTS AND METHODS: A total of 139 patients with surgically resected ESCC were retrospectively analyzed,...

Read the complete abstract on PubMed

Topics

Humans
Lymphocytes, Tumor-Infiltrating
Tumor Microenvironment
Esophageal Squamous Cell Carcinoma
Esophageal Neoplasms
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Prognosis

Retrospective Studies

Phenotype

Aged

Source

Identifiers

PMID: 42674688
DOI: 10.21873/anticanres.18357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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