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Article

ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.

Kidney international - 1 Sept 2024

Jiang Quan, Song Guiyu, He Liying, Li Xue, Jiang Bo, Wang Qianxun, Wang Shaoxun, Kim Catherine, Barkestani Mahsa Nouri, Lopez Roberto, Fan Matthew, Wanniarachchi Kujani, Quaranta Maya, Tian Xuefei, Mani Arya, Gonzalez Anjelica, Goodwin Julie E, Sessa William C, Ishibe Shuta, Jane-Wit Dan

Abstract excerpt

ZFYVE21 is an ancient, endosome-associated protein that is highly expressed in endothelial cells (ECs) but whose function(s) in vivo are undefined. Here, we identified ZFYVE21 as an essential regulator of vascular barrier function in the aging kidney. ZFYVE21 levels significantly decline in ECs in aged human and mouse kidneys. To investigate attendant effects, we generated EC-specific Zfyve21-/- reporter mice....

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Source

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Identifiers

PMID: 38797325
DOI: 10.1016/j.kint.2024.05.007
PMCID: PMC11343665

Genes

ZFYVE21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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