Article
Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function.
Science signaling - 14 Oct 2014
Liu Xiaolei, Pasula Satish, Song Hoogeun, Tessneer Kandice L, Dong Yunzhou, Hahn Scott, Yago Tadayuki, Brophy Megan L, Chang Baojun, Cai Xiaofeng, Wu Hao, McManus John, Ichise Hirotake, Georgescu Constantin, Wren Jonathan D, Griffin Courtney, Xia Lijun, Srinivasan R Sathish, Chen Hong
Abstract excerpt
Lymphatic valves prevent the backflow of the lymph fluid and ensure proper lymphatic drainage throughout the body. Local accumulation of lymphatic fluid in tissues, a condition called lymphedema, is common in individuals with malformed lymphatic valves. The vascular endothelial growth factor rece...
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