Article

Loss of phosphatidylserine flippase β-subunit <i>Tmem30a</i> in podocytes leads to albuminuria and glomerulosclerosis

2020-12-05

Abstract excerpt

Phosphatidylserine (PS) is asymmetrically concentrated in the cytoplasmic leaflet of eukaryotic cell plasma membranes. This asymmetry is regulated by a group of P4 ATPases (named PS flippases) and its β-subunit TMEM30A. The disruption of PS flippase leads to severe human diseases. Tmem30a is essential in the mouse retina, cerebellum and liver. However, the role of Tmem30a in the kidney, where it is highly expres...

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Literature Corpus work: 0138cf18-5682-54a8-b2a5-0fd5dd6b4f3a
DOI: 10.1101/2020.12.04.412635

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