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Article

Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 25 May 2024

Akay-Espinoza Cagla, Newton Sarah E B, Dombroski Beth A, Kallianpur Asha, Bharti Ajay, Franklin Donald R, Schellenberg Gerard D, Heaton Robert K, Grant Igor, Ellis Ronald J, Letendre Scott L, Jordan-Sciutto Kelly L

Abstract excerpt

Based on emerging evidence on the role for specific single-nucleotide variants (SNVs) in EIF2AK3 encoding the integrated stress response kinase PERK, in neurodegeneration, we assessed the association of EIF2AK3 SNVs with neurocognitive performance in people with HIV (PWH) using a candidate gene approach. This retrospective study included the CHARTER cohort participants, excluding those with severe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38789639
DOI: 10.1007/s11481-024-10125-x
PMCID: PMC11126443

Genes

EIF2AK3
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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