Article
Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2012
Levine Andrew J, Service Susan, Miller Eric N, Reynolds Sandra M, Singer Elyse J, Shapshak Paul, Martin Eileen M, Sacktor Ned, Becker James T, Jacobson Lisa P, Thompson Paul, Freimer Nelson
Abstract excerpt
The neuropathogenesis of HIV-associated neurocognitive disorders (HAND) is unclear. Candidate gene studies have implicated genetic susceptibility loci within immune-related genes; however, these have not been reliably validated. Here, we employed genome-wide association (GWA) methods to discover novel genetic susceptibility loci associated with HAND, and validate susceptibility loci implicated in prior candidate...
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