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Elucidating the Role of MicroRNA-18a in Propelling a Hybrid Epithelial-Mesenchymal Phenotype and Driving Malignant Progression in ER-Negative Breast Cancer.

Cells - 10 May 2024

Nair Madhumathy G, Mavatkar Apoorva D, Naidu Chandrakala M, V P Snijesh, C E Anupama, Rajarajan Savitha, Sahoo Sarthak, Mohan Gayathri, Jaikumar Vishnu Sunil, Ramesh Rakesh S, B S Srinath, Jolly Mohit Kumar, Maliekal Tessy Thomas, Prabhu Jyothi S

Abstract excerpt

Epigenetic alterations that lead to differential expression of microRNAs (miRNAs/miR) are known to regulate tumour cell states, epithelial-mesenchymal transition (EMT) and the progression to metastasis in breast cancer. This study explores the key contribution of miRNA-18a in mediating a hybrid E/M cell state that is pivotal to the malignant transformation and tumour progression in the aggressive ER-negative...

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Source

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Identifiers

PMID: 38786043
DOI: 10.3390/cells13100821
PMCID: PMC11119613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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