Article
Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer.
Oncogene - 1 Jul 2023
Sample Reilly A, Nogueira Marina F, Mitra Robi D, Puram Sidharth V
Abstract excerpt
Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor invasion and metastasis. Recent efforts to understand EMT biology have uncovered that cells undergoing EMT attain a spectrum of intermediate "hybrid E/M" states, which exist along an epithelial-mesenchymal continuum. Here, we...
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