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Article

Mutational signatures of colorectal cancers according to distinct computational workflows.

Briefings in bioinformatics - 23 May 2024

Battuello Paolo, Corti Giorgio, Bartolini Alice, Lorenzato Annalisa, Sogari Alberto, Russo Mariangela, Di Nicolantonio Federica, Bardelli Alberto, Crisafulli Giovanni

Abstract excerpt

Tumor mutational signatures have gained prominence in cancer research, yet the lack of standardized methods hinders reproducibility and robustness. Leveraging colorectal cancer (CRC) as a model, we explored the influence of computational parameters on mutational signature analyses across 230 CRC cell lines and 152 CRC patients. Results were validated in three independent datasets: 483 endometrial cancer patients...

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Identifiers

PMID: 38783705
DOI: 10.1093/bib/bbae249
PMCID: PMC11116831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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