Article
Deciphering gene contributions and etiologies of somatic mutational signatures of cancer.
Briefings in bioinformatics - 19 Mar 2023
Ji Xiangwen, Wang Edwin, Cui Qinghua
Abstract excerpt
Somatic mutational signatures (MSs) identified by genome sequencing play important roles in exploring the cause and development of cancer. Thus far, many such signatures have been identified, and some of them do imply causes of cancer. However, a major bottleneck is that we do not know the potential meanings (i.e. carcinogenesis or biological functions) and contributing genes for most of them. Here, we presented...
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