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Article

Tumour evolution in hepatocellular carcinoma.

Nature reviews. Gastroenterology & hepatology - 1 Mar 2020

Craig Amanda J, von Felden Johann, Garcia-Lezana Teresa, Sarcognato Samantha, Villanueva Augusto

Abstract excerpt

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically develops on the background of chronic liver disease and is an aggressive disease with dismal prognosis. Studies using next-generation sequencing of multiple regions of the same tumour nodule suggest different patterns of HCC evolution and confirm the high molecular heterogeneity in a subset of patients. Different hypotheses...

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Source

Identifiers

PMID: 31792430
DOI: 10.1038/s41575-019-0229-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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