Article
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma.
Nature communications - 27 Feb 2017
Zhai Weiwei, Lim Tony Kiat-Hon, Zhang Tong, Phang Su-Ting, Tiang Zenia, Guan Peiyong, Ng Ming-Hwee, Lim Jia Qi, Yao Fei, Li Zheng, Ng Poh Yong, Yan Jie, Goh Brian K, Chung Alexander Yaw-Fui, Choo Su-Pin, Khor Chiea Chuen, Soon Wendy Wei-Jia, Sung Ken Wing-Kin, Foo Roger Sik-Yin, Chow Pierce Kah-Hoe
Abstract excerpt
Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversification. Unlike the variegated pattern found in colorectal cancers, a large proportion of HCC display a clear...
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