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Article

Ductal carcinoma in situ develops within clonal fields of mutant cells in morphologically normal ducts.

The Journal of pathology - 1 Jul 2024

Hutten Stefan J, Messal Hendrik A, Lips Esther H, Sheinman Michael, Ciwinska Marta, Braams Esmee, van der Borden Carolien, Kristel Petra, Stoffers Saskia, Wessels Lodewyk Fa, Jonkers Jos, van Rheenen Jacco, Wesseling Jelle, Scheele Colinda Lgj

Abstract excerpt

Mutations are abundantly present in tissues of healthy individuals, including the breast epithelium. Yet it remains unknown whether mutant cells directly induce lesion formation or first spread, leading to a field of mutant cells that is predisposed towards lesion formation. To study the clonal and spatial relationships between morphologically normal breast epithelium adjacent to pre-cancerous lesions, we...

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Share to Breast Neoplasms
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Copy Number Variations

Share to Imaging, Three-Dimensional

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Identifiers

PMID: 38779852
DOI: 10.1002/path.6289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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