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Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes.

Science translational medicine - 22 May 2024

Chen Zhuo, Satake Eiichiro, Pezzolesi Marcus G, Md Dom Zaipul I, Stucki Devorah, Kobayashi Hiroki, Syreeni Anna, Johnson Adam T, Wu Xiwei, Dahlström Emma H, King Jaxon B, Groop Per-Henrik, Rich Stephen S, Sandholm Niina, Krolewski Andrzej S, Natarajan Rama

Abstract excerpt

Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been implicated in the etiology of progressive diabetic kidney disease (DKD). However, the specific mechanisms linking DNAmet variation in blood cells with risk of kidney failure (KF) and utility of measuring blood cell DNAmet in personalized medicine are not clear. We measured blood cell DNAmet in 277 individuals with type 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38776390
DOI: 10.1126/scitranslmed.adj3385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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