Article
Cytosine methylation predicts renal function decline in American Indians.
Kidney international - 1 Jun 2018
Qiu Chengxiang, Hanson Robert L, Fufaa Gudeta, Kobes Sayuko, Gluck Caroline, Huang Jing, Chen Yong, Raj Dominic, Nelson Robert G, Knowler William C, Susztak Katalin
Abstract excerpt
Diabetic nephropathy accounts for most of the excess mortality in individuals with diabetes, but the molecular mechanisms by which nephropathy develops are largely unknown. Here we tested cytosine methylation levels at 397,063 genomic CpG sites for association with decline in the estimated glomerular filtration rate (eGFR) over a six year period in 181 diabetic Pima Indians. Methylation levels at 77 sites showed...
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