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Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes

12 Jan 2023

Abstract excerpt

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene expression. This is particularly challenging for DN because genome-wide methylation patterns are poorly defined....

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PMID: 36633903
DOI: 10.1172/jci160959

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