Distinct methylation patterns in genes that affect mitochondrial function are associated with kidney disease in blood‐derived DNA from individuals with Type 1 diabetes

Abstract excerpt

AIMS: Epigenetic modifications, such as DNA methylation, can influence the risk of developing kidney disease. We studied methylation profiles in genes related to mitochondrial function to assess whether differences in these epigenetic features were associated with diabetic kidney disease in people with Type 1 diabetes. METHODS: A case-control association study was undertaken (n = 196 individuals with diabetic...

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