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Article

FLT3-ITD regulation of the endoplasmic reticulum functions in acute myeloid leukemia.

Hematological oncology - 1 May 2024

Turos-Cabal María, Sánchez-Sánchez Ana M, Puente-Moncada Noelia, Herrera Federico, Antolin Isaac, Rodríguez Carmen, Martín Vanesa

Abstract excerpt

The FLT3-ITD mutation represents the most frequent genetic alteration in newly diagnosed acute myeloid leukemia (AML) patient and is associated with poor prognosis. Mutation result in the retention of a constitutively active form of this receptor in the endoplasmic reticulum (ER) and the subsequent modification of its downstream effectors. Here, we assessed the impact of such retention on ER homeostasis and found...

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Identifiers

PMID: 38775115
DOI: 10.1002/hon.3281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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