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Article

Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation.

Cancer letters - 28 Jul 2016

Huang Amin, Ju Huai-Qiang, Liu Kaiyan, Zhan Guilian, Liu Daolu, Wen Shijun, Garcia-Manero Guillermo, Huang Peng, Hu Yumin

Abstract excerpt

Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant cell lines carrying FLT3/ITD mutations, including the murine BaF3/ITD-R and human MV4-11-R cell...

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Identifiers

PMID: 27132990
DOI: 10.1016/j.canlet.2016.04.040

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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