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Article

Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells.

Oncology reports - 1 Jul 2020

Puente-Moncada Noelia, Turos-Cabal Maria, Sánchez-Sánchez Ana M, Antolín Isaac, Herrera Federico, Rodriguez-Blanco Jezabel, Duarte-Olivenza Cristina, Rodriguez Carmen, Martín Vanesa

Abstract excerpt

The FMS‑like tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation represents the most frequent genetic alteration in acute myeloid leukemia (AML) and is associated with poor prognosis. The mutation promotes cancer cell survival and proliferation, and shifts their glucose metabolism towards aerobic glycolysis, a frequent alteration in cancer. In the present study, the impact of melatonin on the...

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Identifiers

PMID: 32319665
DOI: 10.3892/or.2020.7584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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