Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of PTM of FLT3 in acute myeloid leukemia.

Acta biochimica et biophysica Sinica - 24 Jun 2024

Liu Jianwei, Gu Jianguo

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expressed in hematopoietic cells. Internal-tandem duplication domain (ITD) mutation and tyrosine kinase domain (TKD) mutation are the two most common mutations in acute myeloid leukemia (AML). Post-translational modifications (PTMs) of FLT3, such as glycosylation and ubiquitination, have been shown to impact various aspects of the protein in both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to fms-Like Tyrosine Kinase 3
Share to Glycosylation
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Kinase Inhibitors

Share to Protein Processing, Post-Translational

Share to Signal Transduction

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 38915288
DOI: 10.3724/abbs.2024112
PMCID: PMC11399421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of PTM of FLT3 in acute myeloid leukemia.PMID 38915288Read ↗

Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication.Semantic proximity Read ↗

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.Semantic proximity Read ↗

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cellsSemantic proximity Read ↗

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.Semantic proximity Read ↗

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications.Semantic proximity Read ↗

Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.Semantic proximity Read ↗

Survey of activated FLT3 signaling in leukemia.Semantic proximity Read ↗

Identification of Flt3 internal tandem duplications downstream targets by high-throughput immunoblotting protein array system.Semantic proximity Read ↗

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.Semantic proximity Read ↗

BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia.Semantic proximity Read ↗

Functional impact of glycosylation of LRIG1 on EGFR proteostasis in cancer.Semantic proximity Read ↗

Functional Impact of Glycosylation and Splicing Variants of LRIG1 on EGFR Proteostasis in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.