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Article

Utilizing genetics and proteomics to assess the role of antihypertensive drugs in human longevity and the underlying pathways: a Mendelian randomization study.

European heart journal. Cardiovascular pharmacotherapy - 4 Oct 2024

Fan Bohan, Zhao Jie V

Abstract excerpt

BACKGROUND: Antihypertensive drugs are known to lower cardiovascular mortality, but the role of different types of antihypertensive drugs in lifespan has not been clarified. Moreover, the underlying mechanisms remain unclear. METHODS AND RESULTS: To minimize confounding, we used Mendelian randomization to assess the role of different antihypertensive drug classes in longevity and examined the pathways via...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38769606
DOI: 10.1093/ehjcvp/pvae038

Genes

CDH1
CPT2
ADRB1
CACNA2D2
CACNB3
CPT1A
EDNRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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